When people think of the Pfizer COVID-19 vaccine, one of the first thoughts or questions usually concerns the extremely low temperature requirements to maintain the vaccine’s potency. But, how can you really know if you’re doing a good job in preserving the vaccines’ potency? Per the CDC temperature requirements, Pfizer vaccines will be shipped and arrive at a storage facility between -80°C and -60°C (-112°F to -76°F) in a thermal shipping container with dry ice.